Animal age list5/30/2023 ![]() ![]() Des raisons pratiques justifiant le choix de l’âge des rongeurs ont été fréquemment avancées, l’augmentation des coûts liés à l’utilisation d’animaux plus âgés et le maintien de la comparabilité des données historiques étant deux importants facteurs limitatifs. L’âge que les répondants estimaient « adulte » variait entre 6 et 20 semaines. D’après les 297 répondants fournissant 611 réponses, les chercheurs ont constaté que les rongeurs utilisés avaient le plus souvent de 6 à 20 semaines d’âge, indépendamment de la biologie faisant l’objet de l’étude. Les auteurs ont mené une enquête pour évaluer l’âge utilisé dans une gamme de modèles, et le raisonnement motivant le choix de l’âge. L’âge, un facteur important dans la conception expérimentale, est souvent mal pris en compte dans les rapports et peut être négligé. ![]() Il existe un nombre croissant de preuves montrant que l’amélioration de la conception expérimentale est essentielle à l’amélioration de la nature prédictive des études menées sur des rongeurs, ainsi qu’à la réduction du nombre d’animaux utilisés en recherche. Les modèles murins produisent des données qui sous-tendent la recherche biomédicale ainsi que les essais non-cliniques de médicaments, mais il est rare que les données issues des rongeurs se transforment en résultats cliniques réussis. ![]() Increased scientific rigour in the choice of the age of rodent may increase the translation of rodent models to humans. ![]() In some cases the use of older animals may be beneficial. This could potentially result in decreased scientific validity and increased experimental variability. These results highlight that choice of age is inconsistent across the research community and often not based on the development or cellular ageing of the system being studied. Practical reasons for the choice of rodent age were frequently given, with increased cost associated with using older animals and maintenance of historical data comparability being two important limiting factors. The age referred to as ‘adult’ by respondents varied between six and 20 weeks. From 297 respondents providing 611 responses, researchers reported using rodents most often in the 6–20 week age range regardless of the biology being studied. The authors conducted a survey to assess the age used for a range of models, and the reasoning for age choice. Age, one important factor in experimental design, is often poorly reported and can be overlooked. There is a growing body of evidence showing that improving experimental design is key to improving the predictive nature of rodent studies and reducing the number of animals used in research. Rodent models produce data which underpin biomedical research and non-clinical drug trials, but translation from rodents into successful clinical outcomes is often lacking. All subjects Allied Health Cardiology & Cardiovascular Medicine Dentistry Emergency Medicine & Critical Care Endocrinology & Metabolism Environmental Science General Medicine Geriatrics Infectious Diseases Medico-legal Neurology Nursing Nutrition Obstetrics & Gynecology Oncology Orthopaedics & Sports Medicine Otolaryngology Palliative Medicine & Chronic Care Pediatrics Pharmacology & Toxicology Psychiatry & Psychology Public Health Pulmonary & Respiratory Medicine Radiology Research Methods & Evaluation Rheumatology Surgery Tropical Medicine Veterinary Medicine Cell Biology Clinical Biochemistry Environmental Science Life Sciences Neuroscience Pharmacology & Toxicology Biomedical Engineering Engineering & Computing Environmental Engineering Materials Science Anthropology & Archaeology Communication & Media Studies Criminology & Criminal Justice Cultural Studies Economics & Development Education Environmental Studies Ethnic Studies Family Studies Gender Studies Geography Gerontology & Aging Group Studies History Information Science Interpersonal Violence Language & Linguistics Law Management & Organization Studies Marketing & Hospitality Music Peace Studies & Conflict Resolution Philosophy Politics & International Relations Psychoanalysis Psychology & Counseling Public Administration Regional Studies Religion Research Methods & Evaluation Science & Society Studies Social Work & Social Policy Sociology Special Education Urban Studies & Planning BROWSE JOURNALS ![]()
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